Tendinopathy is one of the common disorders in sports medicine and is usually characterized by pain,swelling,and impaired function.The pathogenesis of tendinopathy has not been fully elucidated until now.In clinical practice,tendinopathy is still treated conservatively and there is no good treatment yet.Mitochondria,as energy supply factories for cellular life activities,play an important role in regulating apoptosis,autophagy,and necrosis.Currently,mitochondria can be used as a potential strategy for the treatment of tendinopathy,this article focuses on the role of mitochondrial dysfunction in the pathogenesis of tendinopathy and the application of mitochondria in the treatment of tendinopathy,which will help to further explore the feasibility of the mitochondrial pathway in the treatment of tendinopathy.