可溶性尿激酶型纤溶酶原激活物受体在童年创伤及抑郁症中的研究进展
Research advances of soluble urokinase plasminogen activator receptor in childhood trauma and major depressive disorder
许腾欢 1张慧凤 1卢文仙 1彭代辉1
作者信息
- 1. 上海交通大学医学院附属上海市精神卫生中心 上海 200030
- 折叠
摘要
可溶性尿激酶型纤溶酶原激活物受体(suPAR)是一种在炎症状态下由尿激酶型纤溶酶原激活受体(uPAR)切割或脱落产生的可溶性蛋白.由于其性质稳定,能更可靠地反映持续或慢性感染,近年来被广泛用作研究疾病中新型炎症的生物标志物.本文旨在综述suPAR与童年创伤经历及抑郁症的相关研究.在童年创伤及抑郁症方面,suPAR在基础和临床研究中都显示出极大的潜在应用价值,将在未来的研究中继续发挥重要作用.
Abstract
Soluble urokinase plasminogen activator receptor(suPAR)is a soluble protein produced by the cleavage or shedding of the urokinase plasminogen activator receptor(uPAR)during inflammatory conditions.Because of its stable nature,suPAR is a more reliable indicator of persistent or chronic infection than traditional inflammatory markers and has been used in recent years as a novel biomarker of inflammation in diseases.This article aims to summarize the research on the relationship between suPAR and childhood trauma experience and depression.In the future,there is still great practical value in the direction of childhood trauma and depression,concerning the role of suPAR in basic and clinical research.
关键词
可溶性尿激酶型纤溶酶原激活物受体/炎症/抑郁症/童年创伤Key words
Soluble Urokinase Plasminogen Activator Receptor/Inflammation/Depression/Childhood Trauma引用本文复制引用
基金项目
国家自然科学基金项目(82201678)
上海市青年科技启明星计划(扬帆专项)项目(22YF1439100)
上海市科学技术委员会项目(YDZX2021310000131003)
出版年
2024
NETL
NSTL
万方数据