中老年男性2型糖尿病患者葡萄糖目标范围内时间、糖化血红蛋白与骨质疏松的相关性
Association of time in range and glycosylated hemoglobin with osteoporosis in middle-aged and elderly male patients with type 2 diabetes mellitus
丁家豪 1林萱 2崔静 2吴嘉慧 1柯璐1
作者信息
- 1. 武汉科技大学医学部医学院 湖北 武汉 430065
- 2. 武汉科技大学附属华润武钢总医院内分泌科 湖北 武汉 430080
- 折叠
摘要
目的:研究中老年男性2型糖尿病(T2DM)患者葡萄糖目标范围内时间(TIR)和糖化血红蛋白(HbA1c)与骨质疏松(OP)的相关性.方法:纳入中老年男性T2DM患者300例,采用双能X线吸收法检测患者腰椎1～4、双侧髋关节骨密度(BMD),根据BMD的T值将研究对象分为骨质疏松组、骨量减少组、骨量正常组.多因素Logistic回归分析法分析T2DM患者TIR、HbA1c与OP的相关性.采用受试者工作特征(ROC)曲线分析TIR、HbA1c预测中老年男性T2DM患者发生OP的价值.结果:T2DM骨质疏松组TIR水平明显低于骨量正常组和骨量减少组(P<0.05).T2DM骨质疏松组HbA1c水平明显高于骨量正常组和骨量减少组(P<0.05).多因素Logistic回归分析显示,HbA1c是中老年男性T2DM患者发生OP的独立危险因素(P<0.05);TIR是中老年男性T2DM患者发生OP的独立保护因素(P<0.05).ROC曲线分析结果显示:TIR、HbA1c预测中老年男性T2DM患者发生OP风险的ROC曲线下面积(AUC)面积分别为0.951和0.748.结论:TIR、HbA1c均与中老年男性T2DM患者发生OP相关,均可预测中老年男性T2DM患者发生OP的风险,且监测T2DM患者TIR值比HbA1c值能更好地对OP发生风险进行预测.
Abstract
Objective:To investigate the association of time in range(TIR)and glycosylated hemoglobin(HbA1c)with osteoporosis(OP)in middle-aged and elderly male patients with type 2 diabetes mellitus(T2DM).Methods:A total of 300 middle-aged and elderly male patients with T2DM were enrolled.Dual-energy X-ray absorptiometry was used to detect the bone mineral density(BMD)of lumbar verte-brae 1-4 and bilateral hip joints.According to the T value of BMD,the subjects were divided into the osteoporosis group,osteopenia group,and normal bone mass group.Multivariate Logistic regression analysis was used to analyze the correlation between TIR,HbA1c,and OP in T2DM patients.The receiver operating characteristic(ROC)curve was used to analyze the value of TIR and HbA1c in pre-dicting OP in middle-aged and elderly male patients with T2DM.Results:The level of TIR in the T2DM osteoporosis group was significantly lower than that in the normal bone mass group and the os-teopenia group(P<0.05).The level of HbA1c in T2DM osteoporosis group was significantly higher than that in normal bone mass group and osteopenia group(P<0.05).Multivariate Logistic regres-sion analysis showed that HbA1c was an independent risk factor for OP in middle-aged and elderly male patients with T2DM(P<0.05).TIR was an independent protective factor for OP in middle-aged and elderly male patients with T2DM(P<0.05).ROC curve analysis results showed that the ar-ea under the curve(AUC)of TIR and HbA1c for predicting OP risk in middle-aged and elderly men with T2DM were 0.951 and 0.748,respectively.Conclusion:Both TIR and HbA1c are associated with OP in middle-aged and elderly men with T2DM,and can predict the risk of OP in middle-aged and elderly men with T2DM,and monitoring TIR value in T2DM patients can better predict the risk of OP than monitoring HbA1c value.
关键词
2型糖尿病/骨质疏松/葡萄糖目标范围内时间/糖化血红蛋白/持续葡萄糖监测Key words
Type 2 Diabetes Mellitus/Osteoporosis/Time in Range/Glycosylated Hemoglo-bin/Continuous Glucose Monitoring引用本文复制引用
基金项目
湖北省微循环学科研资助基金(HBWXH20181-6)
出版年
2024
NETL
NSTL
万方数据