Association of time in range and glycosylated hemoglobin with osteoporosis in middle-aged and elderly male patients with type 2 diabetes mellitus
Objective:To investigate the association of time in range(TIR)and glycosylated hemoglobin(HbA1c)with osteoporosis(OP)in middle-aged and elderly male patients with type 2 diabetes mellitus(T2DM).Methods:A total of 300 middle-aged and elderly male patients with T2DM were enrolled.Dual-energy X-ray absorptiometry was used to detect the bone mineral density(BMD)of lumbar verte-brae 1-4 and bilateral hip joints.According to the T value of BMD,the subjects were divided into the osteoporosis group,osteopenia group,and normal bone mass group.Multivariate Logistic regression analysis was used to analyze the correlation between TIR,HbA1c,and OP in T2DM patients.The receiver operating characteristic(ROC)curve was used to analyze the value of TIR and HbA1c in pre-dicting OP in middle-aged and elderly male patients with T2DM.Results:The level of TIR in the T2DM osteoporosis group was significantly lower than that in the normal bone mass group and the os-teopenia group(P<0.05).The level of HbA1c in T2DM osteoporosis group was significantly higher than that in normal bone mass group and osteopenia group(P<0.05).Multivariate Logistic regres-sion analysis showed that HbA1c was an independent risk factor for OP in middle-aged and elderly male patients with T2DM(P<0.05).TIR was an independent protective factor for OP in middle-aged and elderly male patients with T2DM(P<0.05).ROC curve analysis results showed that the ar-ea under the curve(AUC)of TIR and HbA1c for predicting OP risk in middle-aged and elderly men with T2DM were 0.951 and 0.748,respectively.Conclusion:Both TIR and HbA1c are associated with OP in middle-aged and elderly men with T2DM,and can predict the risk of OP in middle-aged and elderly men with T2DM,and monitoring TIR value in T2DM patients can better predict the risk of OP than monitoring HbA1c value.
Type 2 Diabetes MellitusOsteoporosisTime in RangeGlycosylated Hemoglo-binContinuous Glucose Monitoring
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