Analysis of the efficacy of LASSO-Logistic diagnostic model based on sequential organ failure assessment score in sepsis
Objective:To analyze the relevant factors affecting the occurrence of sepsis using LASSO-Logistics,to construct the efficacy of a sequential organ failure assessment(SOFA)score-based diagnostic model for sepsis,and to conduct in-depth validation.Methods:This study retrospectively collected clinical data of critically ill patients,including laboratory test indicators,ad-mitted to the Department of Critical Care Medicine(CCM)of Huanggang Central Hospital affiliated to Yangtze University between July 2020 and October 2022 within 24 hours of admission,and used the SOFA score to assess patients'organ dysfunction.Patients were divided into sepsis and non-sepsis groups based on their diagnosis on admission to the intensive care unit,and variables were initially screened using a LASSO regression model,and a sepsis diagnostic model was developed using multi-factorial logistic regression to calculate the area under the curve(AUC).Results:A total of 235 pa-tients were included,and 130 were diagnosed with sepsis and 105 without.LASSO-logistic analysis showed that antithrombin Ⅲ active substance(ATⅢ),fibrinogen(FIB),hypersensitive C-reactive protein(hs-CRP),and SOFA were assessed as independent risk factors,and a joint diagnostic model was constructed.The joint model with an AUC value of 0.928(95%CI:0.896-0.960)was better than each indicator(P<0.05),with better generalization ability by the ten-fold cross-validated sugges-tive model.Conclusion:The LASSO-logistic diagnostic model was constructed based on the SOFA score,which showed better predictive efficacy and generalization ability for sepsis diagnosis and could improve the early diagnosis of septic patients.
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