Objective:To investigate the clinical features and magnetic resonance imaging(MRI)changes of necrotizing enterocolitis(NEC)complicated with brain injury in premature infants.Methods:We ret-rospectively analyzed the clinical data of 94 infants with NEC stageⅡ or Ⅲ.The cases were divided into an observation group(35 cases)with abnormal brain MRI and a control group(59 cases)with nor-mal brain MRI.The general clinical data,laboratory examination,and brain MRI of the two groups were studied.Results:Compared with that respectively in the control group,the incidence of NEC stageⅢ,neonatal sepsis,or patent ductus arteriosus(PDA)in the observation group was higher(P<0.05);platelet count decreased and prothrombin time(PT)prolonged in the observation group,with statistically significant difference(P<0.05).The incidence of NEC complicated with brain injury was 37.23%.Compared with the findings of the brain MRI between NEC stageⅡ and stageⅢ,the incidence of NEC stageⅢ brain injury was higher(51.22%vs 26.41%,P=0.014),and more severe brain injury was found,manifested as severe white matter injury(P<0.01)and grade Ⅲ-Ⅳperiventricular-intraventricular hemorrhage(P<0.01).A higher mortality rate was found in NEC stageⅢ patients with brain injury.Conclusion:Neonatal sepsis,PDA,thrombocytopenia,and PT prolon-gation are more likely to cause brain injury in premature NEC.Compared with that in the NEC stageⅡ,brain injury in the NEC stageⅢ is common and more serious.
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