免疫债下儿童呼吸道合胞病毒感染的临床分析
Clinical analysis of respiratory syncytial virus infection in immunologically impaired children
周文静 1裴桂英 2姜赤秋3
作者信息
- 1. 江汉大学医学部 湖北 武汉 430056
- 2. 湖北省第三人民医院儿科 湖北 武汉 430030
- 3. 湖北省第三人民医院新生儿科 湖北 武汉 430030
- 折叠
摘要
目的:探讨国家对新型冠状病毒感染实施"乙类乙管"疫情防控政策,个人非药物干预(NPIs)的减少后,在免疫债的影响下儿童呼吸道感染中呼吸道合胞病毒(RSV)感染临床特征.方法:选取2023年4-5月湖北省第三人民医院阳逻院区儿科收治的儿童呼吸道感染中病原体为RSV感染患儿的临床资料做相关回顾性分析.结果:在707例呼吸道感染患儿中,检出RSV 282例,阳性率39.9%.2023年4-5月为RSV流行高峰.RSV单一感染比例为51.1%(144例/282例),RSV合并其他病原体感染占比48.9%(138例/282例);在144例RSV单一感染患儿中,男女比例为 1.2(79∶65),年龄分布大多在 3～5 岁.住院时长多在 5～6 d(63.2%).以咳嗽(100%)、发热(82.6%)、双肺呼吸音粗(95.1%)较常见,喘息(11.6%)的发生率较低.肺炎发生率为95.8%,重症肺炎发生率为8.7%.结论:(1)免疫债的影响下RSV感染反季节流行,春末夏初(4-5月份)已进入流行期.(2)免疫债的影响下RSV感染患儿年龄多分布在3～5岁,其次为1～2岁.(3)此次RSV感染患儿喘息发生率较低,症状大多以发热、咳嗽为主.(4)RSV感染患儿易引起机体免疫功能紊乱.(5)免疫债的影响下RSV混合感染也有所增加.
Abstract
Objective:To explore the clinical characteristics of children with respiratory tract infection of re-spiratory syncytial virus(RSV)under the influence of immunity debt,after the implementation of the"category B management"policy in China for the prevention and control of COVID-19 epidemic and the reduction of non-pharmaceutical interventions(NPIs).Methods:A retrospective analysis was made on the clinical data of the children with respiratory tract infection of RSV in Yangluo District of the Third People's Hospital of Hubei Province from April 2023 to May 2023.Results:Among the 707 children with respiratory tract infections,282 were detected with RSV,with a positive rate of 39.9%.April to May 2023 was the peak season for RSV infection.The proportion of RSV single in-fection was 51.1%(144/282),and the proportion of RSV co-infection with other pathogens was 48.9%(138/282);among the 144 children with RSV single infection,the male-to-female ratio was 1.2(79∶65),and the age distribution was mostly 3-5 years.Most patients were hospitalized for 5 to 6 days(63.2%).Cough(100%),fever(82.6%)and coarse breath sounds(95.1%)in both lungs were common,and wheezing(11.6%)was less common.The incidence of pneumonia was 95.8%and that of severe pneumonia was 8.7%.Conclusion:Under the influence of immunity debt,RSV infec-tions were counter-seasonal,entering the epidemic period in late spring and early summer(April to May).Most children infected with RSV were 3 to 5 years old,followed by those aged 1 to 2 years.The incidence of wheezing among these children was low,with symptoms primarily consisting of fe-ver and cough.Furthermore,RSV infections can easily lead to immune function disorders,and the occurrence of RSV co-infections has also increased as a result of immunity debt.
关键词
免疫债/非药物干预/呼吸道合胞病毒/急性呼吸道感染Key words
Immunity Debt/Non-Pharmaceutical Interventions/Respiratory Syncytial Virus/Acute Respiratory Tract Infection引用本文复制引用
出版年
2024
NETL
NSTL
万方数据