Objective:To explore the application potential of spatiotemporal fractionation in stereotactic body radiation therapy(SBRT)for central non-small cell lung cancer(NSCLC)due to the risks associ-ated with large fractionations.Methods:Twenty patients with centrally located NSCLC and large tu-mor volumes were retrospectively analyzed.SBRT plans and spatiotemporal fractionation plans were designed for each patient,and the two treatment strategies were compared and evaluated using dose-volume histograms and dose statistics parameters.Results:Spatiotemporal fractionation significantly reduced the physical doses and equieffective dose EQD10 of normal organs while ensuring plan target volume(PTV)doses equivalent to SBRT.The physical doses of the lungs,spinal cord,heart,tra-chea/main bronchi,and esophagus were reduced by(11.16±0.37)%,(10.5±1.42)%,(16.6±0.49)%,(18.28±0.55)%,(18.58±1.34)%,respectively,and EQD10 values were reduced by(13.44±0.34)%,(10.03±1.44)%,(11.93±0.52)%,(22.26±0.52)%,and(25.5±1.23)%,re-spectively.Conclusion:Compared with SBRT,spatiotemporal fractionation can effectively reduce the damage to surrounding normal tissues while ensuring tumor control,thus improving the safety and effectiveness of large fractionation treatment for centrally located NSCLC.
关键词
中央型非小细胞肺癌/时空分割/立体定向放射治疗/物理剂量/生物等效剂量/剂量体积直方图/安全性
Key words
Central Non-Small Cell Lung Cancer/Spatiotemporal Fractionation/Stereotactic Body Radiation Therapy/Physical Dose/Biological Equivalent Dose/Dose-Volume Histogram/Safety
维普
万方数据