Application of spatiotemporal fractionation in stereotactic body radiation therapy for central non-small cell lung cancer
Objective:To explore the application potential of spatiotemporal fractionation in stereotactic body radiation therapy(SBRT)for central non-small cell lung cancer(NSCLC)due to the risks associ-ated with large fractionations.Methods:Twenty patients with centrally located NSCLC and large tu-mor volumes were retrospectively analyzed.SBRT plans and spatiotemporal fractionation plans were designed for each patient,and the two treatment strategies were compared and evaluated using dose-volume histograms and dose statistics parameters.Results:Spatiotemporal fractionation significantly reduced the physical doses and equieffective dose EQD10 of normal organs while ensuring plan target volume(PTV)doses equivalent to SBRT.The physical doses of the lungs,spinal cord,heart,tra-chea/main bronchi,and esophagus were reduced by(11.16±0.37)%,(10.5±1.42)%,(16.6±0.49)%,(18.28±0.55)%,(18.58±1.34)%,respectively,and EQD10 values were reduced by(13.44±0.34)%,(10.03±1.44)%,(11.93±0.52)%,(22.26±0.52)%,and(25.5±1.23)%,re-spectively.Conclusion:Compared with SBRT,spatiotemporal fractionation can effectively reduce the damage to surrounding normal tissues while ensuring tumor control,thus improving the safety and effectiveness of large fractionation treatment for centrally located NSCLC.
Central Non-Small Cell Lung CancerSpatiotemporal FractionationStereotactic Body Radiation TherapyPhysical DoseBiological Equivalent DoseDose-Volume HistogramSafety
万方数据
维普
