Objective:To explore the effect of premature rupture of membranes(PROM)on neonatal out-comes in pregnant women with gestational diabetes mellitus(GDM)by propensity score matching(PSM).Methods:A total of 5 656 singleton GDM pregnant women who delivered at a maternal and child hospital in Chongqing from July 2017 to June 2020 with live birth outcomes were selected,and the GDM pregnant women were divided into the PROM group and control group.Baseline characteristics of women with GDM and neonates were matched 1∶1 by PSM,and the difference in the incidence of adverse neonatal outcomes between the two groups of GDM pregnant women was compared.Logistic regression was used to analyze pre-matching and post-matching data to explore the association between PROM and adverse neonatal outcomes.Results:After PSM,1 531 pregnant women with GDM were enrolled in PROM groups and control group,and the covariates were balanced between the two groups after matching(P>0.05);the results of logistic regression analyses indicated that PROM increased the risk of preterm birth(AOR(95%CI):4.855(3.563-6.741),P<0.001),low birth weight infants(AOR(95%CI):2.648(1.862-3.831),P<0.001)and neonatal hy-perbilirubinemia(AOR(95%CI):2.073(1.576-2.745),P<0.001)in pregnant women with GDM,but the risk of macrosomia(AOR(95%CI):0.568(0.393-0.813),P<0.05)was reduced.Conclu-sion:Pregnant women with GDM who develop PROM have a higher risk of neonatal complications such as preterm birth,low birth weight,and neonatal hyperbilirubinemia in newborns.
Gestational Diabetes MellitusPremature Rupture of MembranesPropensity Score MatchingNeonatal OutcomePregnant Women
万方数据
维普
