The incidence of coronary atherosclerosis has been increasing in recent years,with acute myocardial infarction as its most severe onset.The main clinical treatment aim is to restore myocardial blood supply by recanalizing coronary circulation as early as possible.The existing issue of microcirculation thromboembolism has become an obstacle.Thrombus elimination in coronary microcirculation is crucial and essential to improve the treatment effect of acute myocardial infarction.In recent years,sonothrombolysis has effectively solved the problem of vascular thromboembolism,including microcirculation thromboembolism,and the treatment method is expected to obtain satisfied thrombolytic treatment effect with microthrombus elimination in coronary microvessels and function recovery of terminal microcirculation,which has potential clinical value for the establishment of novel treatment method for coronary thromboembolism.Thus,this paper reviews sonothrombolysis for the application exploration in coronary artery thromboembolism treatment,the mechanism of treatment action,and its research progress.