Osteoarthritis is the most common age-related chronic disease,mainly affecting the movement joints.The pathogenesis of osteoarthritis is complex and closely related to environmental factors,which can participate in the pathogenesis and progression of osteoarthritis through epigenetic modifications.Epigenetic modifications include DNA methylation,histone modification,microRNA,and long non-coding RNA.DNA methylation is a stable epigenetic change of CpG islands that participates in various pathological and physiological processes.The study of single-gene methylation and whole-genome methylation has revealed the important role of DNA methylation in the pathological process of osteoarthritis.DNA methylation is involved in the physiological and pathological processes of chondrocytes such as chondrocyte synthesis,catabolism,inflammatory response,and oxidative stress by regulating gene expression.This article reviews the current research on DNA methylation related to osteoarthritis to gain a more comprehensive understanding of the genes and molecular signaling pathways involved in osteoarthritis pathology and provide a theoretical basis for the diagnosis and intervention treatment of clinical osteoarthritis.
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维普
