Meta-analysis of the association between sleep duration and hyperuricemia
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维普
万方数据
目的:通过整合目前的流行病学数据,探究睡眠时长与高尿酸血症之间的剂量-反应关系.方法:在PubMed、Embase、Web of Science以及PsycINFO数据库中检索截至2023年6月6前符合纳入标准的观察性研究.使用比值比(OR)作为效应量,并基于随机效应模型进行合并.使用限制立方样条模型进行剂量-反应Meta回归分析.结果:经筛选,本研究纳入了来自7项横断面研究的9个独立样本,共计57 233名参与者,其中9 861(17.2%;95%CI:16.9%～17.5%)人确诊高尿酸血症.质量评估显示其中5项为高质量研究,2项研究为中等质量.Egger检验提示显著异质性,故采用随机效应模型合并.与正常睡眠时长(6～8 h)相比,短睡眠时长(<6 h)的合并OR值为1.12(95%CI:1.02～1.22),长睡眠时长(≥8 h)的合并OR值为1.05(95%CI:0.94～1.18).亚组分析表明,平均体质量指数较高的人群中,短睡眠时长与高尿酸血症的正相关性更强.剂量-反应Meta分析显示,睡眠时长与高尿酸血症风险之间存在近似L形的关联,其拐点出现在7.5 h处.结论:睡眠时间过短与高尿酸血症风险增高显著相关,而睡眠时间过长与高尿酸血症无显著关联.本研究建议人们每晚睡眠≥7.5 h以降低高尿酸血症风险.
Objective:To investigate the dose-response relationship between sleep duration and hyperurice-mia by integrating currently available epidemiological data.Methods:PubMed,Embase,Web of Science,and PsycINFO were searched up to June 6,2023,for eligible observational studies.Odds ratios(OR)were used as the effect sizes and combined based on random-effects models.A restricted cubic spline model was adopted in the dose-response meta-analysis.Results:Nine independent sam-ples from seven cross-sectional studies with 57 233 participants were included.Among them,9 861(17.2%;95%CI:16.9%-17.5%)hyperuricemia cases were identified.The quality assessment showed that five studies were of high quality,and two were of moderate quality.Egger tests suggest-ed significant heterogeneity;thus,random-effects models were used.Compared with normal sleep du-ration(6-8 h),the combined OR for short sleep duration(<6 h)was 1.12(95%CI:1.02-1.22),and the combined OR for long sleep duration(≥8 h)was 1.05(95%CI:0.94-1.18).Subgroup analyses indicated a stronger positive association between short sleep duration and hyperuricemia among the population with higher body mass index(BMI).The dose-response meta-analysis showed an approxi-mately L-shaped association between sleep duration and hyperuricemia risk,with the inflection point at 7.5 h.Conclusion:Short sleep duration was significantly associated with a higher risk of hyperuri-cemia,whereas long sleep duration was not.This study suggests people sleep for≥7.5 h/night to maintain a low hyperuricemia risk.
维普
万方数据
