17型胶原蛋白治疗雄激素性脱发的临床疗效
Clinical efficacy of collagen ⅩⅦ in the treatment of androgenic alopecia
郑永宜 1刘琴 1杨超儒 1黄竹君 1温又霖 1谢君 1宋继权1
作者信息
- 1. 武汉大学中南医院皮肤科 湖北 武汉 430071
- 折叠
摘要
目的:对比研究17型胶原蛋白(胶原蛋白ⅩⅦ)与2 940 nm点阵激光治疗雄激素性脱发的疗效差异.方法:选取2023年3-12月进行雄激素性脱发治疗的患者100例作为研究对象,随机分为3组.试验组采用17型胶原蛋白注射治疗、阳性对照组采用2 940 nm点阵激光治疗、阴性对照组采用生理盐水注射治疗,均每月1次,共3次.检测治疗前后各组患者靶部位终毛密度、毛囊宽度、头皮厚度和毛囊间距.结果:治疗前,三组患者各项指标差异均无统计学意义(P>0.05).治疗3个月后,试验组和阳性对照组患者的终毛密度明显提高,且试验组的终毛密度高于阳性对照组(P<0.05);试验组的毛囊宽度低于阳性对照组,阳性对照组的毛囊宽度低于阴性对照组(P<0.05);真皮层厚度减少(P<0.05),且试验组的真皮层厚度减少大于阳性对照组(P<0.05);试验组及阳性对照组患者的毛囊间距减少(P<0.05).结论:使用17型胶原蛋白注射能够显著改善雄激素性脱发患者症状,促进毛发生长.
Abstract
Objective:To evaluate the effectiveness of collagen ⅩⅦ(COL17)and 2 940 fractional lasers in androgenic alopecia treatment.Methods:Between March 2023 and December 2023,100 androgenic alopecia patients who received treatment were selected as research subjects.The experimental group was treated with recombinant humanized COL17 injection;the positive control group was treated with the 2 940 nm dot matrix laser;the negative control group was treated with normal saline injection.All three groups were treated once a month for three months.The average terminal hair density,hair folli-cle width,and other indicators of each group of patients before and after treatment were recorded to compare the differences in efficacy.Results:Before treatment,all indicators of the three groups of pa-tients showed no statistically significant difference(P>0.05).Three months after treatment,the ter-minal hair density significantly increased in both the experimental and positive control groups,and the density in the experimental group was higher than that in the positive control group(P<0.05).The hair follicle width in the experimental group was lower than that in the positive control group,and the hair follicle width in the positive control group was lower than that in the negative control group(P<0.05).The dermal thickness decreased(P<0.05),and the reduction in dermal thickness was greater in the experimental group than in the positive control group(P<0.05).The hair follicle spacing de-creased in both the experimental and positive control groups(P<0.05).Conclusion:The use of COL17 injection can significantly improve the symptoms of androgenic alopecia and promote hair growth.
关键词
雄激素性脱发/17型胶原蛋白/2/940/nm点阵激光/治疗Key words
Androgenic Alopecia/Collagen ⅩⅦ/2 940 nm Fractional Laser/Treatment引用本文复制引用
出版年
2024
NETL
NSTL
万方数据