Preparation and Characterization of a Slow-Release Starch-Based Flutolanil Agent
A starch-based material was synthesized by grafting polymerization of starch with acrylic acid,hydroxypropyl acrylate,and N-methylol acrylamide by 60Co γ-ray radiation,and it was subsequently loaded with flutolanil to prepare a slow-release flutolanil agent.The stability,drug loading capacity,and slow release performance of the agent under different slow-release methods and temperatures were characterized by transmission electron microscopy,infrared spectroscopy,and kinetic analysis.The results showed that the slow-release agent had better stability than flutolanil powder.It exhibited good slow-release and thermal-responsive release performance with the drug loading capacity of 11.35%.The release kinetics at different temperatures could be fitted by the Korsmeyer Peppas model,with the R2 ranging from 0.990 5 to 0.991 3,indicating that the release followed the Fick's law of diffusion.
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