淀粉基氟酰胺缓释剂的制备及性能研究
Preparation and Characterization of a Slow-Release Starch-Based Flutolanil Agent
吴景 1赵彩凤 2连静 1张乐平 2谢洪科 2郭峰 2刘璐 2邵赛2
作者信息
- 1. 长沙市农业科学研究院,湖南 长沙 410016
- 2. 湖南省核农学与航天育种研究所,湖南 长沙 410125;湖南省农业科学院,湖南 长沙 410125
- 折叠
摘要
以淀粉为基材,利用 60Co γ辐照接枝丙烯酸、丙烯酸羟丙酯、N-羟甲基丙烯酰胺等单体合成淀粉基材料,负载氟酰胺后制得氟酰胺缓释剂.通过扫描电镜、红外光谱和动力学分析,探究氟酰胺缓释剂的稳定性、载药量以及不同缓释方法和不同温度下的缓释性能.结果表明:该缓释剂相较于氟酰胺粉剂具有更优异的稳定性;载药量为 11.35%,具有良好的缓释和温度响应释放性能;不同温度下的释放行为符合Korsmeyer Peppas动力学模型,拟合度为 0.990 5～0.991 3,药物释放机制为Fick扩散.
Abstract
A starch-based material was synthesized by grafting polymerization of starch with acrylic acid,hydroxypropyl acrylate,and N-methylol acrylamide by 60Co γ-ray radiation,and it was subsequently loaded with flutolanil to prepare a slow-release flutolanil agent.The stability,drug loading capacity,and slow release performance of the agent under different slow-release methods and temperatures were characterized by transmission electron microscopy,infrared spectroscopy,and kinetic analysis.The results showed that the slow-release agent had better stability than flutolanil powder.It exhibited good slow-release and thermal-responsive release performance with the drug loading capacity of 11.35%.The release kinetics at different temperatures could be fitted by the Korsmeyer Peppas model,with the R2 ranging from 0.990 5 to 0.991 3,indicating that the release followed the Fick's law of diffusion.
关键词
淀粉/氟酰胺/缓释剂/温度响应/缓释性能Key words
starch/flutolanil/slow-release agent/thermal response/slow release performance引用本文复制引用
基金项目
长沙市农业科研攻关专项(长财预[2023]1号)
湖南省农业科技创新资金项目(2022CX96)
出版年
2024
NETL
NSTL
万方数据