To discover novel antifungal molecules,we designed and synthesized 16 target compounds of N-arylaminomethyl benzyl esters and identified their structures.With kresoxim-methyl as the positive control,the inhibitory effects of the target compounds on 10 common phytopathogenic fungi were determined by the mycelial growth rate method.Furthermore,the toxicity of 5 highly antifungal target compounds to Botryosphaeria dothidea and Alternaria solani was determined.The results showed that all the target compounds inhibited the growth of the 10 tested fungi.Among them,compound B11 had the highest antifungal activity,with the inhibition rates over 80%against 9 tested fungi.In addition,compound B11 demonstrated the inhibition rate of 98.1%against Fusarium sambucinum and the EC50 of 7.6 μg/mL against A.solani.The analysis of structure-activity relationship showed that-F and-Me increased the compound activity,being the dominant functional groups of such compounds.The combination of-F and-Me significantly enhanced the compound activity,which was attributed to the combined effect of dominant functional groups.
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