Synthesis and Antifungal Activity of α,β-Unsaturated Benzyl Carboxylates
Twenty-five unsaturated benzyl carboxylates were designed and synthesized according to the principle of active group splicing.The mycelial growth rate was determined to evaluate the inhibition rates of the compounds on 6 species of phytopathogenic fungi.Furthermore,the compound with the strongest antifungal activity was tested for the safe application in wheat seedlings.The results showed that most of the compounds had obvious inhibitory activity on the tested fungi.The inhibition rates of B9 and B16 on all tested fungi were more than 80%,and the inhibition rates of B2 on 5 species of tested fungi were more than 80%.Compound B9 showed no significant effect on the growth of wheat seedlings,demonstrating high safety.The structure-activity relationship analysis showed that the introduction of halogen atoms in the benzene ring was beneficial to improving the antifungal activity of the compounds.
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维普
