Optimization of the Green Extraction Process of Camptotheca Acuminata Flavonoids by Response Surface Methodology
The extraction process of Fructus Cam ptothecae was optimized by using green deep eutectic solvents(DESs).Twelve kinds of DESs were synthesized,and the highest extraction rate of the DESs combination were screened by using a single factor combined with Box-Behnken response surface method extraction process.The results showed that the optimal process conditions were liquid-to-material ratio of 61∶1,molar ratio of choline chloride to citric acid of 2∶3,water content 20％,extraction time 51 minutes.The extraction rate of total flavonoids from Camptotheca acaciae reached 3.29％,which was 3 times of the traditional organic solvent extraction method.This study laid the foundation for the development and utilization of Camptotheca acuminata,and also provided certain reference for the green extraction of active ingredients of Chinese medicinal materials.
deep eutectic solventCamptotheca acaciaflavonoidsgreen extraction
万方数据
维普
