首页|菲啰啉配位双核铜化合物的合成与抗癌活性研究

菲啰啉配位双核铜化合物的合成与抗癌活性研究

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通过菲啰啉衍生物分别合成两种双核一价铜配合物(Cu1和Cu2).单晶衍射测试表明,Cu1具有头-尾对称结构,其中心的铜离子与4个氮原子配位,呈四面体构型;Cu2的两个金属中心原子由2个配体的4个菲啰啉氮原子和2个卡宾碳原子配位,分别呈四面体和直线型构型.体外细胞毒性研究表明,Cu1和Cu2比顺铂具有更强的抗癌活性.机制研究表明,Cu2能引发癌细胞内线粒体膜电位的变化和活性氧的过量产生,最终导致细胞凋亡.
Synthesis and In Vitro Anticancer Activity of Binuclear Copper Complexes Coordinated with Phenanthroline Derivatives
In this study,two dinuclear monovalent copper complexes(Cu1 and Cu2)were synthesized by using phenanthroline derivatives.Single crystal diffraction analysis revealed that Cu1 possesses a head-tail symmetrical structure with the central copper ion coordinated to four nitrogen atoms,forming a tetrahedral configuration.In contrast,Cu2 has a head-head symmetric structure,two metal central atoms coordinated by four phenanthroline nitrogen atoms and two carbene carbon atoms,forming a tetrahedral and linear configuration.In vitro cytotoxicity studies demonstrated that both Cu1 and Cu2 exhibit stronger anticancer activity than cisplatin.Mechanism indicated that Cu2 induces mitochondrial membrane potential depletion and excessive reactive oxygen species(ROS)production in HCT-116 cells,ultimately leading to cell apoptosis.

phenanthrolinedinuclear copper(I)complexcharacterizationanticancer activity

郑依伦、黄帆、徐露露、顾琳琳、沈超、陈超

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浙江树人学院 生物与环境工程学院,浙江 杭州 310015

菲啰啉 双核铜(I)配合物 表征 抗癌活性

浙江省自然科学基金项目浙江省大学生科技创新活动计划暨新苗人才计划项目

LQ21B0300142023R420019

2024

湖州师范学院学报
湖州师范学院

湖州师范学院学报

影响因子:0.301
ISSN:1009-1734
年,卷(期):2024.46(8)