Terahertz study on the porosity of porous traditional Chinese medicine tablets by effective medium models
Generally,the porosity of traditional Chinese medicine is measured by the destructive method of density mea-surement,but there is a lack of non-destructive quantification methods.As one important non-destructive method,tera-hertz radiation has been used to non-destructively extract the drugs'time-domain and frequency-domain optical informa-tion.For direct compression traditional Chinese medicine tablets,the effective refractive index of various tablets was obtained by different methods of terahertz time-domain signal processing and frequency-domain signal processing.It was found that the effective refractive indices with either signal processing method show a good linear relationship with the porosities of the tablets.The porosity of Puerariae Lobatae Radix tablets was extracted and modeled by linear regres-sion based on four effective medium theory models.The porosity regression model based on the effective refractive in-dex by time-domain signal processing shows better performance on the model interpretation and cross-validation accura-cy,with the best model of the Bruggeman model(RPD=11.3325).It provides support for the process optimization of porous powder preparation of traditional Chinese medicine.
Terahertz spectroscopyeffective refractive indexeffective medium theorythe porosity of traditional Chinese medicine tablet
国家科技期刊平台
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