Based on the high-pressure flow loop device,the synergistic inhibition of DGBE(diethylene glycol butyl ether),PM(propylene glycol methyl ether),EPH(ethylene glycol phenyl ether)and kinetic inhibitor PVP(polyvinylpyrrolidone)on the formation of CO2 hydrate was investigated.The induction time,the relative inhibition performance factor IRP and the initial formation rate of hydrate were obtained by experiments,and compared with the relevant parameters of the compound system of kinetic inhibitor and synergist.The results show that the three synergists can promote the inhibition of PVP,and the best one is EPH,the weaker one is PM,and the weakest is DGBE.The combination of inhibitor and synergist and the increase of additive mass fraction can reduce the initial hydrate formation rate.At the same time,the increase of mass fraction has a certain limit to slow down the initial formation rate.The existence of oil phase in the system can weaken the inhibition performance in the kinetic inhibitor-synergist system.Finally,the synergistic inhibition mechanism of PVP and ethers is proposed.