Synthesis and photodynamic activity of silicon (Ⅳ) phthalocyanine axially modified with nucleoside derivatives
A new silicon phthalocyanine axially di-substituted with 5'-(2',3'-O-isopropyl)-6-chlorine purine moieties(SP1)was prepared and characterized by 1H NMR and HR-MS.The electronic absorption and fluorescence emission spectra showed that this compound was essentially nonaggregated in N,N-dimethyformamide and 1%cremophor EL aqueous solution.SP1 also exhibited efficient singlet oxygen generation ability and a high photodynamic activity against human hepatoma HepG2 cells upon light irradiation,with an IC50 value down to 0.2×10-6mol·L-1.Fluorescence confocal microscopy study indicated that SP1 located preferentially in the mitochondria of the cells.All the results demonstrated that SP1 was highly potential as a new anti-cancer photosensitizer.
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