Synthesis and in vitro antitumor activity of(E)-1,3-diferrocenylprop-2-en-1-one
A novel ferrocenyl chalcone derivative(E)-1,3-diferrocenylprop-2-en-1-one(1)was synthesized and its antitumor activity in vitro was studied.The product(1)was synthesized by solid-phase grinding of acetylferrocene(2)and ferrocenecarboxaldehyde(3)in the presence of potassium hydroxide and anhydrous sodium sulfate.The optimum reaction conditions are as follows:the dosage of anhydrous sodium sulfate is nNa2SO4∶n2=0.5∶1,the amount of potassium hydroxide is nKOH∶n2=1.2∶1,the molar ratio of material is n3∶n2=2.2∶1.Under these conditions,the yield of the product was 69.6％.At last,MTT assay was used to test the in vitro inhibitory activity of the product(1)against hormone-dependent breast cancer MCF-7 and triple-negative breast cancer MDA-MB-231.The results showed that the product(1)had certain inhibitory activity on MCF-7 and MDA-MB-231 cells(IC50 were 29.03 and 28.23μM·L-1,respectively),however,the product(1)had no significant inhibitory activity against normal mammary epithelial cells MCF-10A.The results will provide references for the development of ferrocenylchalcone anti-tumor molecules.
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