Determination of chloride ions and bromine ions in medicinal raw materials γ-cyclodextrin by ion chromatography method
OBJECTIVE The method was established to determine chloride and bromine ions in γ-cyclodextrin.METHODS Ion chromatography method was applied,the separation was performed on a Dionex IonPac AS11-HC(250mm×4mm)by isocratic elution using 12mmol·L-1 potassium hydroxide aqueous solution,the column temperature was set at 30℃,the injection volume was 25μL,and the suppression current was 40mA.RESULTS The method was established to determine chloride and bromine ions in γ-cyclodextrin,which had good linear relationship,and the average recoveries were 96.4％and 102.0％.CONCLUSION The established method has strong specificity,good precision and high accuracy,which can be used for simultaneous determination of chloride and bromine ions in γ-cyclodextrin.
γ-cyclodextrinion chromatography methodchloride ionbromine ion
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