离子色谱法测定γ-环糊精中的氯离子和溴离子
Determination of chloride ions and bromine ions in medicinal raw materials γ-cyclodextrin by ion chromatography method
王丽娟 1兰公剑 1万国盛 1张书华 1徐丹1
作者信息
- 1. 南京正大天晴制药有限公司,江苏 南京 210046
- 折叠
摘要
目的 建立 γ-环糊精中Cl-和Br-的分析方法.方法 采用离子色谱法,色谱柱:Dionex IonPac AS11-HC(250mm × 4mm);淋洗液:12mmol·L-1KOH水溶液,等度洗脱;柱温30℃;进样量25μL;检测器:电导检测器,抑制电流40mA.结果 建立了 γ-环糊精中Cl-和Br-的分析方法,线性关系均良好,平均回收率分别为96.4％和102.0％.结论 所建立的离子色谱法专属性强、精密度好、准确度高,可以作为γ-环糊精中Cl-和Br-的测定方法.
Abstract
OBJECTIVE The method was established to determine chloride and bromine ions in γ-cyclodextrin.METHODS Ion chromatography method was applied,the separation was performed on a Dionex IonPac AS11-HC(250mm×4mm)by isocratic elution using 12mmol·L-1 potassium hydroxide aqueous solution,the column temperature was set at 30℃,the injection volume was 25μL,and the suppression current was 40mA.RESULTS The method was established to determine chloride and bromine ions in γ-cyclodextrin,which had good linear relationship,and the average recoveries were 96.4％and 102.0％.CONCLUSION The established method has strong specificity,good precision and high accuracy,which can be used for simultaneous determination of chloride and bromine ions in γ-cyclodextrin.
关键词
γ-环糊精/离子色谱法/氯离子/溴离子Key words
γ-cyclodextrin/ion chromatography method/chloride ion/bromine ion引用本文复制引用
出版年
2024
NETL
NSTL
万方数据