Supercritical CO2 spraying is a green and efficient spraying technology which has emerged in recent years,and the atomization effect is one of the main factors affecting its spraying quality.The response surface method and the supercritical CO2 spraying device independently developed are used to study the effects of CO2 temperature,CO2 pressure,CO2 mass fraction,and nozzle size on the atomization effect,and the Sauter mean diameter D32 is used as the characterization parameter in this article.The research results indicate that CO2 pressure,CO2 mass fraction,and nozzle size have a significant impact on the atomization effect,and the interaction between CO2 pressure and CO2 mass fraction is significant.The significance of each influencing factor in descending order is nozzle size,CO2 pressure,CO2 mass fraction,and CO2 temperature,and the nozzle size is positively correlated with D32,while the CO2 pressure,CO2 temperature,and CO2 mass fraction are negatively correlated with D32.With the atomization parameters of supercritical CO2 spraying are CO2 pressure of 10 MPa,CO2 temperature of 53℃,CO2 mass fraction of 50%,and nozzle size of 0.33 mm,the optimal D32 of atomized droplets is 69.6 μm.The above research results can provide theoretical guidance for the industrial design and production of supercritical CO2 spraying.