"Click Chemistry" and Its Growing Applications in Biomedical Field
The "click" concept, introduced by Sharpless and coworkers in 2001, is undeniably one of the most important trends in contemporary chemistry. The copper (Ⅰ)-catalyzed click cycloaddition is generally regarded as the quintessential example of click chemistry, because it can proceeds well in aqueous medium and therefore may be efficiently performed under physiological conditions. Moreover, it holds great chemoselectivity and can therefore be used for modifying highly functional biomolecules such as poly-peptides, nucleic acids or polysaccharides. This mini-review will focus on the recent developments appearing within the literature concerning the applications of the click chemistry in drug design, bioconjugation, biomaterials, colloids and planar surfaces.
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