摘要
近年来,作为新一代人工酶的纳米酶,凭借着优于天然酶的多酶活性、高稳定性和靶向性等特点逐步进入医学领域,又因对活性氧的调控作用而被应用于多种疾病及癌症的治疗.脑类疾病作为病死率最高的疾病之一,病理环境中存在过多的活性氧,易产生复杂的炎症反应.因此,将纳米酶应用于脑部环境或成为有效的脑疾病监测和治疗手段.本文综述了纳米酶应用于脑疾病治疗的原理及近年来该领域的研究现状,包括纳米酶通过调控活性氧的水平诱导癌细胞凋亡、纳米酶辅助传统抗癌疗法、纳米酶借助膜蛋白进行脑癌监测以及在创伤性脑损伤、脑卒中、大脑退行性疾病、脑型疟疾和癫痫中的应用.最后,对其应用于临床治疗所面临的问题进行了讨论.
Abstract
In recent years,nanozymes,as a new generation of artificial enzymes,have gradually entered the medical field due to their multi-enzyme activity,high stability and targeting ability,which are superior to natural enzymes.Moreover,nanozymes have been applied to the treatment of a variety of diseases and cancer because of their regulatory effect on reactive oxygen species.Brain diseases,as one of the highest mortality diseases,are prone to produce complex inflammatory responses due to excessive reactive oxygen species in the pathological environment.Therefore,the application of nanozymes in the brain environment may become an effective means of monitoring and treatment of brain diseases.This article reviews the principles of nanozymes in the treatment of brain diseases and the current research status in this field in recent years,including nanozymes inducing cancer cell death by regulating the level of reactive oxygen species,nanozymes assisting traditional anticancer therapy,nanozymes using membrane proteins to monitor brain cancer,and their applications in traumatic brain injury,stroke,brain degenerative diseases,cerebral malaria and epilepsy.At the end of this text,the problems of its application in clinical treatment are discussed.
基金项目
国家自然科学基金项目(82103147)
国家自然科学基金项目(12272253)
山西省基础研究计划项目(20210302124007)
山西省基础研究计划项目(202203021221047)
山西浙大新材料与化工研究院研发项目(2021SX-AT008)
山西浙大新材料与化工研究院研发项目(2021SX-AT009)
NETL
NSTL
万方数据