Synthesis and Application of Ion-Doped Mesoporous Bioactive Glasses
The research and development of bone filling and bone substitute biomaterials is one of the important research directions in the field of bone repair.Mesoporous bioactive glass(MBG)will play an important role in bone repair and regeneration because of its good bioactivity,adjustable pore size and ordered mesoporous structure.MBG with fiber,scaffold,hollow structure or nano-particle structure can be obtained by different preparation and processing methods.Many studies have shown that the incorporation of a small amount of therapeutic inorganic ions into MBG can endow them with more biological properties,including osteogenic,antibacterial,anti-inflammatory,hemostatic or anti-cancer properties.Moreover,MBG doped with inorganic ions still has excellent bioactivity after being processed as scaffolds or nanoparticles.In addition,the performance of MBG can be further improved by loading bioactive molecules,therapeutic drugs and stem cells into the mesoporous structure.In this paper,the synthesis of MBG,the antibacterial properties of metal ion-doped MBG and the application of MBG in other fields are reviewed.
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