Optimizing Metabolic Pathways by Using Bioretrosynthesis Tools
Biocatalysis has become an important technology in the field of biosynthesis because of its mild reaction conditions,high efficiency,high specificity and low price.There are a series of highly integrated metabolic networks in the biosynthesis system,and the study of multi-enzyme catalytic system has become an inevitable trend in the field of biosynthesis,so it is of great significance to explore the unknown multi-enzyme synthesis path based on the known products.In this review,the concepts of multi-enzyme system and retrosynthesis process are introduced.And the design methods,advantages and disadvantages of retrosynthesis tools are summarized.Then the tools are divided into host-based and host-less tools.For each of these two types,some representative retrosynthesis tools are listed to analyze their respective design processes and differences.Finally,the possibility of artificial intelligence-assisted multi-enzyme system is discussed and the optimization and development of multi-enzyme pathway construction tools are forecasted.
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