摘要
药械组合医用生物材料通过药物与器械的有机组合为传统医用装置的发展提供了广阔的前景.随着临床需求不断升级,开发新型表界面工程技术及药物控释机制成为研究的热点.近年来,聚合物材料多孔表界面技术通过毛细吸附作用实现功能分子与器械的快速组合,具有负载灵活、剂量可控、释放可调的特点,为推动医用生物材料药械组合的精准化、个性化提供新的潜力.本综述首先对聚合物材料多孔表界面的制备进行了总结,包括呼吸图法、模板法、表面非溶剂诱导相分离法、刺激诱导相分离法和静电纺丝法,然后阐述了基于聚合物材料多孔表界面的功能分子递送的机理和释放行为研究,接着归纳了聚合物材料多孔表界面在靶向抗癌、心血管植介入材料、骨修复材料等领域的相关研究进展,最后总结了当今聚合物多孔表界面研究面临的挑战,并对其发展方向进行了展望.
Abstract
Combination products present significant opportunities for advancing traditional medical devices by versatile integration of therapeutic drugs and devices.As clinical needs evolve,there remains growing interest in developing new surface and interface engineering technologies for modulating drug delivery behavior.Recently,polymeric porous surface interface technology has emerged as a robust strategy for the flexible amalgamation of functional molecules with medical devices via capillary adsorption.In comparison to the conventional coating method,this technology shows distinctive features like flexible loading,facile dosage control,and tunable release,therefore providing a novel insight for personalized medicine.This review begins by outlining the methods for preparing porous surfaces of polymer materials,including the breath figure,template method,surface non-solvent-induced phase separation,stimulus-induced phase separation method,and electrospinning method.Then,the mechanism for the capillary-based loading process and hindered release behavior of functional species,which play a central role in the development of spongy surface-based combination devices,is discussed.This review also provides an overview of the latest research on the porous surface interfaces of polymer materials in applications like targeted anti-cancer,cardiovascular implants,and bone repair,summarizes the present challenges in research on the porous surfaces of polymer materials,and highlights insights into potential future directions.
基金项目
国家自然科学基金项目(U20A20262)
国家自然科学基金项目(51933009)
国家自然科学基金项目(52203190)
中央高校基本科研业务费专项资金(226-2023-00108)
NETL
NSTL
万方数据