Polymeric Porous Surface Materials:Construction and Drug Delivery Applications
Combination products present significant opportunities for advancing traditional medical devices by versatile integration of therapeutic drugs and devices.As clinical needs evolve,there remains growing interest in developing new surface and interface engineering technologies for modulating drug delivery behavior.Recently,polymeric porous surface interface technology has emerged as a robust strategy for the flexible amalgamation of functional molecules with medical devices via capillary adsorption.In comparison to the conventional coating method,this technology shows distinctive features like flexible loading,facile dosage control,and tunable release,therefore providing a novel insight for personalized medicine.This review begins by outlining the methods for preparing porous surfaces of polymer materials,including the breath figure,template method,surface non-solvent-induced phase separation,stimulus-induced phase separation method,and electrospinning method.Then,the mechanism for the capillary-based loading process and hindered release behavior of functional species,which play a central role in the development of spongy surface-based combination devices,is discussed.This review also provides an overview of the latest research on the porous surface interfaces of polymer materials in applications like targeted anti-cancer,cardiovascular implants,and bone repair,summarizes the present challenges in research on the porous surfaces of polymer materials,and highlights insights into potential future directions.
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