摘要
干扰细菌的铁代谢是一种不易引起细菌耐药性的非抗生素类抗菌策略.本文首先介绍了一种既能杀死耐药细菌,又不易引起细菌耐药性的铁阻断抗菌疗法;接着从细菌的铁摄取途径和血红素摄取途径分别阐述了铁阻断抗菌疗法的机理;然后重点评述了镓盐类和卟啉镓类铁阻断抗菌剂的种类、体外抗菌性和活体治疗效果;最后对基于铁阻断机理的抗菌剂的研发趋势及应用前景进行了展望.
Abstract
Interfering with bacterial iron metabolism is a non-antibiotic antibacterial strategy that is not easy to cause bacterial resistance.In this review,firstly,an iron-blocking antibacterial therapy which can kill drug-resistant bacteria but not easily cause drug resistance is introduced.Then,the mechanism of iron-blocking antibacterial therapy is explained from the iron uptake pathway and heme uptake pathway of bacteria.In addition,the types,in vitro antibacterial properties,and in vivo therapeutic effects of the iron blocking antimicrobials based on gallium salts and gallium porphyrins are reviewed in detail.Finally,the future development and practical application of the antimicrobials based on iron-blocking mechanism are prospected.
基金项目
国家自然科学基金项目(21961132005)
中海油服创新创造项目(HYZC-3-20240329-41577)
维普
万方数据