Iron-Blocking Antibacterial Agents Based on Gallium Salts or Gallium Porphyrins
Interfering with bacterial iron metabolism is a non-antibiotic antibacterial strategy that is not easy to cause bacterial resistance.In this review,firstly,an iron-blocking antibacterial therapy which can kill drug-resistant bacteria but not easily cause drug resistance is introduced.Then,the mechanism of iron-blocking antibacterial therapy is explained from the iron uptake pathway and heme uptake pathway of bacteria.In addition,the types,in vitro antibacterial properties,and in vivo therapeutic effects of the iron blocking antimicrobials based on gallium salts and gallium porphyrins are reviewed in detail.Finally,the future development and practical application of the antimicrobials based on iron-blocking mechanism are prospected.
drug resistancegallium nitrategallium porphyrinsiron-blocking antibacterial therapies
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维普
