Effect of Hericium Erinaceus Polysaccharide on Inflammatory Factors and Immunoglobulin in CNP Rat Model
To explore the effect of Hericium erinaceus polysaccharide on inflammatory factors(TNF-α,IL-6,IFN-γ),immunoglobulin(IgA,IgG)and specific enzymes(ACP,PAP)in chronic nonbacterial prostatitis(CNP)rat model,and to provide reference for the application of Hericium erinaceus polysaccharide in the treat-ment of chronic nonbacterial prostatitis,seventy SPF SD rats were used to establish a rat model of nonbacterial pros-tatitis by injecting carrageenan.After successful modeling,they were randomly divided into blank group,model group,Qianlietai group and low,medium and high dose groups of Hericium erinaceus polysaccharide.The changes of inflammatory factors,immunoglobulin,total acid phosphatase(ACP)and prostate specific acid phosphatase(PAP)in each group were observed after 42 days of administration.After the end of administration,the levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interferon-γ(IFN-γ)and immunoglobulin A(IgA)in the Qianlietai group,Hericium erinaceus polysaccharide low,medium and high dose groups were signifi-cantly lower than those in the model group(P<0.01).The levels of immunoglobulin G(IgG)in Qianlietai group and Hericium erinaceus polysaccharide medium and high dose groups were significantly lower than those in the model group(P<0.01).The levels of total acid phosphatase(ACP)and prostate-specific acid phospha-tase(PAP)in Qianlietai group and high-dose Hericium erinaceus polysaccharide group were significantly de-creased(P<0.01).The pathogenesis of chronic nonbacterial prostatitis is related to the increase of inflammatory factors(TNF-α,IL-6,IFN-γ),the expression of immunoglobulin(IgA,IgG)and the activity of specific en-zymes(ACP,PAP)in serum.Hericium erinaceus polysaccharide can reduce the content of inflammatory factors,control the expression of immunoglobulin and inhibit the activity of specific enzymes to play a therapeutic role.
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