基于NaIO3转化NaIO4回用合成S-甘油醛缩丙酮及其寡聚研究
Synthesis and Oligomerization of S-Glyceraldehyde Acetonide Based on the Conversion of NaIO3 to NaIO4
张珍明 1季姜钰 1彭晓含 1张疏航 2刘若雨 1李润莱3
作者信息
- 1. 江苏海洋大学环境与化工学院,江苏连云港 222005
- 2. 灌南森迪门业有限公司,江苏连云港 222500
- 3. 四川大学高分子材料与工程学院,四川成都 610065
- 折叠
摘要
S-甘油醛缩丙酮是合成手性药物的重要中间体.以L-抗坏血酸为原料,经缩酮化,硼氢化钠还原,高碘酸钠氧化制得S-甘油醛缩丙酮,收率为46.8％;探讨了含碘酸钠母液转化成高碘酸钠以循环套用,回收率为83.90％;初步考察了 S-甘油醛缩丙酮的聚合度与时间的关系,并推测其寡聚化合物的结构和反应机理;用1HNMR、IR和LC-MS等对化合物结构进行表征.
Abstract
S-glyceraldehyde acetonide is an important intermediate for the synthesis of chiral drugs.L-ascorbic acid was used as raw material to synthesize S-glyceraldehyde acetonide with a yield of 47.2％,after ketalization,sodium borohydride reduction and sodium periodate oxidation.The mother liquor containing sodium iodate was transformed into sodium periodate for reusing with a recovery rate of 83.90％.The relationship between the degree of polymerization of S-glyceraldehyde acetonide and time was investigated,and reaction mechanism of its oligomerization was speculated.The structure of the compound was characterized by 1H NMR,IR and LC-MS.
关键词
S-甘油醛缩丙酮/L-抗坏血酸/高碘酸钠/循环利用/合成/寡聚Key words
S-glyceraldehyde acetonide/L-ascorbic acid/sodium periodate/synthesis/recycling/oligomeriza-tion引用本文复制引用
基金项目
国家自然科学基金青年基金(52103042)
江苏省苏北科技专项(SZ_LYG202017)
江苏省可见光催化材料工程研究中心开放课题(JECVCM202204)
江苏省研究生科研与实践创新计划(KYCX2021-042)
江苏省大学生创新创业训练计划(SY202111641637005)
出版年
2024
NETL
NSTL
万方数据