首页|基于NaIO3转化NaIO4回用合成S-甘油醛缩丙酮及其寡聚研究

基于NaIO3转化NaIO4回用合成S-甘油醛缩丙酮及其寡聚研究

扫码查看
原文链接
  • NETL
  • NSTL
  • 万方数据
S-甘油醛缩丙酮是合成手性药物的重要中间体.以L-抗坏血酸为原料,经缩酮化,硼氢化钠还原,高碘酸钠氧化制得S-甘油醛缩丙酮,收率为46.8％;探讨了含碘酸钠母液转化成高碘酸钠以循环套用,回收率为83.90％;初步考察了 S-甘油醛缩丙酮的聚合度与时间的关系,并推测其寡聚化合物的结构和反应机理;用1HNMR、IR和LC-MS等对化合物结构进行表征.
Synthesis and Oligomerization of S-Glyceraldehyde Acetonide Based on the Conversion of NaIO3 to NaIO4
S-glyceraldehyde acetonide is an important intermediate for the synthesis of chiral drugs.L-ascorbic acid was used as raw material to synthesize S-glyceraldehyde acetonide with a yield of 47.2％,after ketalization,sodium borohydride reduction and sodium periodate oxidation.The mother liquor containing sodium iodate was transformed into sodium periodate for reusing with a recovery rate of 83.90％.The relationship between the degree of polymerization of S-glyceraldehyde acetonide and time was investigated,and reaction mechanism of its oligomerization was speculated.The structure of the compound was characterized by 1H NMR,IR and LC-MS.

S-glyceraldehyde acetonideL-ascorbic acidsodium periodatesynthesisrecyclingoligomeriza-tion

张珍明、季姜钰、彭晓含、张疏航、刘若雨、李润莱

展开 >

江苏海洋大学环境与化工学院,江苏连云港 222005

灌南森迪门业有限公司,江苏连云港 222500

四川大学高分子材料与工程学院,四川成都 610065

S-甘油醛缩丙酮 L-抗坏血酸 高碘酸钠 循环利用 合成 寡聚

国家自然科学基金青年基金江苏省苏北科技专项江苏省可见光催化材料工程研究中心开放课题江苏省研究生科研与实践创新计划江苏省大学生创新创业训练计划

52103042SZ_LYG202017JECVCM202204KYCX2021-042SY202111641637005

2024

10.19500/j.cnki.0367-6358.20220806

化学世界
上海市化学化工学会

化学世界

影响因子：0.264
ISSN：0367-6358
年,卷(期)：2024.65(3)
  • 2