Study and Application of Environmental Protection Process of Cefotiam
The 3-position intermediate of cefotiam(7-ACMT)was synthesized from 7-amino-cephalosporanic acid(7-ACA)and 1-(2-dimethylaminoethyl)-1H-5-mercaptotetrazole(MTZ)in dimethyl carbonate,a green environmentally friendly solvent.After hydrolysis,7-ACMT was directly condensed with aminothiazole acetyl chloride hydrochloride(7-position side chain)to produce cefotiam without separation.A one-pot process was adopted to obtain a simplified technological process.The solvent ratio and process conditions were optimized to simplify the process.The types and quantity of organic solvents were reduced for cost reduction.Thus,a more environment friendly process is obtained.The results showed that the organic solvent used in this method is easy to degrade and less toxic,which is beneficial to the recovery and utilization of the process.The product quality score is 99.0%,the color grade of product was controlled below 2#,and the quality score of unknown impurity was controlled below 0.15%to meet the quality requirements of domestic and foreign customers and to be more suitable for industrial production applications.