用于间质液检测的微针阵列研究进展
Advances of the Microneedle Array for Interstitial Fluid Detection
裴家梦 1张国军 1李玉桃 1唐丽娜1
作者信息
- 1. 湖北中医药大学检验学院 湖北时珍实验室 武汉 430065
- 折叠
摘要
间质液是疾病诊断生物标志物的重要来源.微针阵列(MNs)作为一种微创技术进入皮下间质液可以避免接触血管和神经,使用时疼痛感较小,易被患者接受,在多种领域都有广泛的应用.使用MNs检测间质液可以为临床诊断提供更多信息,研发制备简单、稳定性强和功能多样的MNs逐渐成为研究热点.本文介绍了间质液中生物标志物检测对人体健康监测的重要意义,总结了用于间质液检测的MNs的分类以及MNs制备所使用材料,着重介绍了 MNs在间质液中采样与检测应用,讨论了 MNs在间质液检测中的发展前景以及面临的挑战.
Abstract
Interstitial fluid is an important source of biomarkers for disease diagnosis.As a minimally invasive technique,microneedle array can avoid contact with blood vessels and nerves when entering subcutaneous interstitial fluid,resulting in less pain and easy acceptance by patients.It has been widely used in various fields.The use of microneedle arrays to detect interstitial fluid can provide more information for clinical diagnosis.The preparation process of microneedle arrays is relatively simple and has multiple functions and high stability.Therefore,microneedle arrays have gradually become a research hotspot.This paper not only introduces the important significance of detecting biomarkers in interstitial fluid for human health monitoring,but also summarizes the classification of microneedle arrays for interstitial fluid detection and the materials used in their preparation.Finally,this article focuses on the application of microneedle arrays in sampling and detection of interstitial fluid,and discusses the development prospects and challenges of microneedle arrays in interstitial fluid detection.
关键词
微针阵列/间质液/生物传感/疾病诊断Key words
Microneedle array/Interstitial fluid/Biosensors/Disease diagnosis引用本文复制引用
基金项目
湖北省中医药局项目(ZY2023F136)
出版年
2024
NETL
NSTL
维普
万方数据