Research Progress in Biomarker Detection Methods based on Aptamers
Aptamer is oligonucleotide chain that can bind to specific target molecule.Due to their characteristics of easy modification,easy synthesis and low immunogenicity,aptamers have been widely used as target components for biosensors in biomarker detection technology.This article reviews the research progress of aptamer-based biomarker detection in cancer,cardiovascular disease,Alzheimer's disease,depression and other diseases in recent years,lists the innovative application of emerging technologies of aptamers,with the aim to provide new ideas for the detection of biomarkers,it is also expected to provide reference for the early diagnosis and treatment of related diseases.