Progress in the Synthesis of the Anticancer Drug Tevozanib
Renal cell carcinoma,also known as renal carcinoma,is one of the most common invasive malignant tumors,and for advanced renal cell carcinoma,drug treatment is particularly crucial.Tivozanib,a small molecule targeted new drug,is an oral,potent,highly selective,and safe VEGFR tyrosine kinase receptor inhibitor with significant anti-tumor and anti angiogenic effects,and has broad market application prospects.This article summarizes the synthesis methods and crystal types of Tivozanib,and discusses the advantages and disadvantages of each synthesis method,providing assistance for the synthesis research and industrial production of Tivozanib and its intermediates.
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