Syntheses and Anticancer Activities of Chalcone Mannich Base Derivatives
Starting from paeonol and p-chlorobenzaldehyde,the target compounds paeonol mannich base derivatives(4a～4e,5a～5e)were obtained through Claisen-Schmidt and Mannich reactions.The chemical structure of target compounds was confirmed by HRMS,1H NMR and 13C NMR.The in vitro antiproliferative activities of the synthesized compounds were assessed against human cancer cell lines(HepG2 and A549).The results showed that the target compounds had strong cell proliferation inhibitory effects on tumor cells A549 and HepG2,and were significantly superior to the positive control drug 5-fluorouracil.
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