Research Progress in Stimulation Response Nano-Drug Delivery System based on Hyaluronic Acid
Hyaluronic acid(HA)is a natural polysaccharide with good biocompatibility and biodegradability.The nanocarriers constructed with HA have tumor-targeting functions and can be used as anticancer drug carriers to deliver drugs into the tumor cells for the treatment of the disease.In recent years,more and more attention has been paid to the application of HA in tumor-targeted drug delivery systems,which have become a research hotspot in tumor-targeted therapy.Based on the essential characteristics of HA and the physiological basis of tumor targeting,the HA-based nano drug delivery systems can release the drug in the microenvironment of the tumor to kill tumor cells under different stimuli responses and avoid drug damage to other normal tissues.This article mainly reviews the latest research progress of HA-based nano-drug delivery systems for drug release in response to various stimuli.
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