Luteolin is a flavonoid compound,mainly present in the form of glycosides in vegetables,fruits and Chinese herbs.Luteolin has a variety of biological activities,can regulate many intracellular and extracellular signaling pathways related to disease progression,and has antioxidant,anti-inflammatory,anti diabetes,anti-cancer and other effects.However,the low solubility and bioavailability limit its clinical application.Therefore,researchers have designed and synthesized luteolin derivatives with better solubility,improved bioavailability,and enhanced activity through various methods,in order to attenuate its adverse factors,and then play a role in the prevention and treatment of disease.This article reviews the research progress in luteolin derivatives,providing reference for the research,development,and utilization of natural products.
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