Research Progress in Hydroxamic Acids Based on Histone Deacetylases Targets and Their Antitumor Activities
Tumor therapy includes histone deacetylases(HDACs)as one of its targets.Through a variety of ways,histone deacetylase inhibitors(HDACi)are significant in their anti-tumor performance.It involves the stimulation of apoptosis,DNA repair,angiogenesis,invasion,migration,and viability of tumor cells.This review examined the synthesis and antitumor activity of derivatives of hydroxamic acid that had HDACs as single and multi-targets in recent years.Meanwhile prospects were made regarding the trend of development and potential applications in this area.
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维普
