Preparation and Application of Phenylalanine Derivative Chiral Gel
Chiral supramolecular gel show potential application prospects in sensors,artificial antennae,sustained drug release,cell culture and other fields.In this work,novel D/L phenylalanine chiral gel factors ALP and ADP containing azobenzene functional group were synthesized,which have symmetrical and completely opposite chiral signals.The gel factor can form a stable yellow gel in a variety of mixture of organic solvents and water.The optimal gel-forming performance was in mixture of DMSO and water,and the critical gel-forming concentration can reach 2.0 mg/mL,indicating that the chiral gel factor has good gel-forming properties.The chiral gel also responded to external environmental stimuli such as heat,light,pH,etc.,accompanied by macroscopic observable gel-sol mutual transformation.Chiral gel factor self-assembly formed different helical nanofiber structures,and it was found that L-type chiral nanofibers had better adhesion and proliferation effects on cells than D-type chiral nanofibers.
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