表面增强拉曼光谱在细菌耐药性评价方面的研究进展
Research Advances in SERS Technology for Assessing Bacterial Drug Resistance
黄梓萱 1李芷瑶 1朱怡亭 1张桐 1文有青 1王海霞2
作者信息
- 1. 天津中医药大学中药制药工程学院 天津 301617
- 2. 天津中医药大学中药制药工程学院 天津 301617;天津市中药智能制药与绿色制药重点实验室 天津 301617
- 折叠
摘要
细菌耐药性问题引发全球关注.表面增强拉曼光谱技术(SERS)凭借灵敏度高、检测速度快等优势在评价细菌耐药性应用方面备受关注.本文首先总结了与细菌耐药性评价相关的SERS基底及检测方法,然后对SERS光谱技术在耐药菌和敏感菌鉴定、细菌生物膜成膜性分析与评价及抗菌药物敏感性筛查方面的应用进行总结,最后对SERS技术在细菌检测方面的一些瓶颈问题展开了讨论.希望本文能为SERS技术在细菌耐药性评价方面的应用提供方法指导和思路借鉴.
Abstract
The problem of bacterial drug resistance has attracted global attention.Surface enhanced Raman spectroscopy(SERS)technology has attracted much attention in evaluating bacterial drug resistance applications due to its advantages of high sensitivity and fast detection speed.This article first summarizes the SERS substrates and detection methods related to the evaluation of bacterial resistance.Then,it summarizes the application of SERS spectroscopy technology in the identification of resistant and sensitive bacteria,analysis and evaluation of bacterial biofilm formation,and screening of antimicrobial susceptibility.Finally,some bottleneck issues of SERS technology in bacterial detection are discussed.It is hoped that this review will provide methodological guidance and ideas for the application of SERS technology in the evaluation of bacterial resistance.
关键词
表面增强拉曼光谱/耐药性评价/纳米基底/快速筛查Key words
Surface enhanced Raman spectroscopy(SERS)/Drug resistance evaluation/Nanosubstrates/Rapid screening引用本文复制引用
出版年
2024
NETL
NSTL
万方数据