Research Progress in Anti-Tumor Effects Types of Ursolic Acid Derivatives with Different Structural Types
Ursolic acid is a common pentacyclic triterpenoid active product in plants,with broad-spectrum and significant anti-tumor activity.However,its poor water solubility limits its application as an anticancer drug.Therefore,appropriate modification of the structural matrices of ursolic acid and introduction of special pharmacodynamic moieties to improve the limitations of its clinical applications have become a hot topic of current research.This review summarizes various synthetic derivatives of ursolic acid with anti-tumor activity reported in the last 10 years to explore the effects of different group modifications on anti-tumor activity and provide a reference for studying the structure-activity relationship of ursolic acid in anti-tumor aspects.
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