Preparation and Drug Release Properties of Self-Adhesive,NIR-Responsive Hydrogels
Hydrogel is a kind of hydrophilic three-dimensional network structure,which has good biocompatibility and can provide a good support structure for cell migration and growth,and is often used as a carrier of cells or drugs.However,traditional hydrogels have the limit in responding to external stimuli,which make them difficult to manage the release of drugs in time and space.In this paper,by preparing PDA-PPy nanoparticles and embedding them into PAM/P(NIPAm-co-AAc)hydrogel network,adhesive hydrogels with NIR light response were prepared,and their tensile properties,adhesion properties and NIR drug controllable release properties were discussed.The results showed as follows:1)when the content of PDA-PPy-PAM in the hydrogel increased,the elongation ratio of the hydrogel increased first(from 3 to 5 times)and then decreased,while the fracture stress of the hydrogel decreased gradually from 60 kPa to 30 kPa.2)The prepared hydrogel can form a good adhesion effect on the surface of glass,plastics and human skin.3)The NIR photothermal conversion rate of hydrogel is affected by the nanometer content of PDA-PPy,and increases with the increase of nanoparticle content.When the content of nanoparticles is 1.8(wt)％,the temperature of hydrogel can reach about 45 ℃ after 10 min irradiation under NIR.4)Under NIR radiation,the drug release of the hydrogel containing tetracycline gradually increased,after 120 min,the drug release reached 65％,and the antibacterial efficiency reached about 100％,while the drug release of the hydrogel not irradiated by NIR was only 5％.
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