Synthesis and Antibacterial Activity of Thiazolidones Containing Indolinone Substituents
A series of thiazolone compounds containing indolinone skeleton were synthesized and their anti-resistant Candida albicans activity was screened.The Friedel-Crafts alkylation reaction was carried out using 4-phenylthiazol-2(3H)-ones with different substituents and 2-phenyl-3H-indole-3-ones with different substituents as starting materials.The reaction conditions such as Cu(OTf)2,Fe(OTf)3,Sc(OTf)3 and achiral phosphoric acid ligands,different temperatures and different solvents were investigated.After determining the optimal reaction conditions,a total of 22 target derivatives were synthesized,and their antifungal activities were studied by microdilution method.The results showed that,except for compounds 17 and 18,which have poor effects,the other 20 compounds have good antifungal activity and are worthy of further exploration and research.
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