药物(S)-布洛芬合成新方法与课程思政实验设计
New Synthetic Method of(S)-Ibuprofen Drug and Ideological & Political Teaching of Experiment Design
陈勃廷 1张振凯 1黄玲林 2贺凤开 1黄毅勇1
作者信息
- 1. 武汉理工大学化学化工与生命科学学院化学系 武汉 430070
- 2. 武汉理工大学材料复合新技术国家重点实验室 武汉 430070
- 折叠
摘要
手性辅基控制的不对称合成是获取手性化合物的重要方法之一,被广泛应用于医药合成领域.基于目前手性布洛芬合成问题,研究团队发展了经Cu(OTf)2催化羰基α-位不对称芳基化反应制备手性药物(S)-布洛芬的合成新方法,并将研究成果转化为本科综合实验教学,可以帮助学生掌握多步有机合成反应操作,理解不对称合成技术对服务国家需求和维护人民生命健康的重要意义.此外,本文对实验所蕴含的思政元素进行充分挖掘,并将之与实验教学环节深入融合,最终培养学生的科学思维、创新能力、团队合作精神、专业认同感和社会责任感.
Abstract
Asymmetric synthesis using chiral auxiliary strategy is one of the important methods for the synthesis of chiral compounds,which is widely used in the field of pharmaceutical synthesis.To address the synthetic challenges posed by chiral ibuprofen,we herein reported a new synthetic method to(S)-ibuprofen via the enantioselective α-arylation of carbonyls catalyzed by Cu(OTf)2.By transforming the research achievement into the undergraduate comprehensive experiments,we hope the students could master the skill of multistep synthesis,and could understand the importance of asymmetric synthesis technology in serving national needs and maintaining human health.The ideological and political elements are fully explored,and deeply integrated with multi-link experimental teaching.The scientific consideration and innovation,as well as and the teamwork cooperation ability are to be cultivated,and also the identity of chemistry major and social responsibility will be improved for undergraduate students.
关键词
不对称合成/手性辅基/课程思政/实验教学Key words
Asymmetric synthesis/Chiral auxiliary/Ideology and politics course/Experimental teaching引用本文复制引用
基金项目
国家自然科学基金项目(22301229)
国家自然科学基金项目(22072111)
国家自然科学基金项目(22372128)
出版年
2024
NETL
NSTL
万方数据