New Synthetic Method of(S)-Ibuprofen Drug and Ideological & Political Teaching of Experiment Design
Asymmetric synthesis using chiral auxiliary strategy is one of the important methods for the synthesis of chiral compounds,which is widely used in the field of pharmaceutical synthesis.To address the synthetic challenges posed by chiral ibuprofen,we herein reported a new synthetic method to(S)-ibuprofen via the enantioselective α-arylation of carbonyls catalyzed by Cu(OTf)2.By transforming the research achievement into the undergraduate comprehensive experiments,we hope the students could master the skill of multistep synthesis,and could understand the importance of asymmetric synthesis technology in serving national needs and maintaining human health.The ideological and political elements are fully explored,and deeply integrated with multi-link experimental teaching.The scientific consideration and innovation,as well as and the teamwork cooperation ability are to be cultivated,and also the identity of chemistry major and social responsibility will be improved for undergraduate students.
Asymmetric synthesisChiral auxiliaryIdeology and politics courseExperimental teaching
NETL
NSTL
万方数据
