Gene expression regulation is a fundamental and intricate process in biology,involving various intra-and extracellular factors as well as the structural dynamics of DNA.While the double helix structure is the canonical form,non-canonical DNA structures such as G-quadruplexes(G4)are widely distributed in crucial genomic regions.These structures participate in gene expression regulation,maintain chromosome stability,and influence telomere elongation.G4 structures are found in both DNA and RNA and are closely associated with gene expression regulation.DNA methylation serves as an epigenetic marker and has been increasingly linked to various diseases,impacting cellular functions.Recent studies have illuminated the association between DNA methylation and diverse pathological conditions.This article aims to review the interplay between G4 structures and DNA methylation,particularly focusing on their mutual influence in CpG(Cytosine-phosphate-Guanine)island regions.It provides insights into novel strategies for the prevention and treatment of relevant diseases.
关键词
G-四链体/DNA甲基化/CpG岛/DNA复制/染色质结构状态
Key words
G-quadruplexes/DNA methylation/CpG island/DNA replication/Chromatin structure state
维普
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