Interaction between G-quadruplex Structure and DNA Methylation:Current Research and Future Perspectives
Gene expression regulation is a fundamental and intricate process in biology,involving various intra-and extracellular factors as well as the structural dynamics of DNA.While the double helix structure is the canonical form,non-canonical DNA structures such as G-quadruplexes(G4)are widely distributed in crucial genomic regions.These structures participate in gene expression regulation,maintain chromosome stability,and influence telomere elongation.G4 structures are found in both DNA and RNA and are closely associated with gene expression regulation.DNA methylation serves as an epigenetic marker and has been increasingly linked to various diseases,impacting cellular functions.Recent studies have illuminated the association between DNA methylation and diverse pathological conditions.This article aims to review the interplay between G4 structures and DNA methylation,particularly focusing on their mutual influence in CpG(Cytosine-phosphate-Guanine)island regions.It provides insights into novel strategies for the prevention and treatment of relevant diseases.
G-quadruplexesDNA methylationCpG islandDNA replicationChromatin structure state
万方数据
维普
