Designer benzodiazepines,a class of designer drugs that modify the structure of traditional benzodiazepines,have been among the fastest-growing new psychoactive substances in recent years.Designer benzodiazepines are structurally diverse,constantly emerging,complex and ever-changing,easy to abuse and addictive,and can also be used to anesthetize and then implement criminal activities,seriously endangering social stability.And how to effectively analyze and test them is the main problem currently facing.This article reviews the research progress in biological sample pretreatment and analysis methods for benzodiazepine class new psychoactive substances in recent years,in order to provide ideas for the subsequent analysis and testing work.Overall,traceability,high sensitivity,automation and miniaturization of on-site testing are the future trends in the analysis and testing of designer benzodiazepines.
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