Synthesis of a flavone derivative and evaluation of its in vitro anti-cancer activity
A flavone derivative, 5-hydroxyl-2-(4-hydroxyphenyl)-7-(2-morpholinoethoxy)-4H-chroxmen-4-one, was synthesized with naringenin as the raw material. The structure of as-synthesized product was characterized by nuclear magnetic resonance spectroscopy, elemental analysis and mass spectrometry. Moreover, the inhibition ratio of the synthesized product for human liver cells (HepG2) and SMMO7721 human hepatoma cell line as well as normal human fetal liver (QSG-7701) was tested with MTT method. Results show that as-synthesized compound has good inhibitory activity against the cells of liver canner.
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维普
