Study on synthesis and NMR spectra of 2-hydroxymethylcyclopentanone
2-Hydroxymethylcyclopentanone was synthesized by ketalization,reduction and deprotection using methyl cyclopentanone-2-carboxylate as the raw material.The reaction condition of the third step was optimized to develop a simple,environmentally friendly,and highly efficient method.Cheap β-cyclodextrin effectively promoted carbonyl deprotection in the aqueous phase,producing the product with 99%yield.The structures of the intermediate and target product were characterized by NMR,and the NMR spectra of its active hydrogen were investigated in detail.In different deuterium reagents,the active hydrogen of the product appears in different positions,which is determined by the exchange of heavy water.
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