Research progress on the application of ruthenium catalysts in dynamic kinetic resolution
Chiral compounds play an important role in organic synthesis and are widely used in the fields of medicine,agriculture,food,and materials.Methods for obtaining single chiral compound have always been an important research topic,however,the general synthesis or extraction methods often obtain racemates.Dynamic kinetic resolution provides a powerful methodology for the complete transformation of racemates into single enantiomers.In dynamic kinetic resolution,one enantiomer is selectively converted to the product with the simultaneous racemization of the other enantiomer,thus affording a high yield approaching 100%with an enantiomeric excess value of>99%.Several groups have explored a series of ruthenium-enzymatic catalytic systems,ruthenium-non-enzymatic catalytic systems,and ruthenium-chiral ligand complexes for dynamic kinetic resolutions of allyl alcohols,diols,and functionalized secondary alcohols,as well as the asymmetric transfer hydrogenation of ketones and esters.This paper provides a review of these dynamic kinetic resolution procedures with detailed examples for each of them to provide a reference for the further application of these methods.
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